PDRN aka "SALMON SPERM" (Polydeoxyribonucleotide)
- nkdskin
- 2 days ago
- 2 min read

Salmon DNA, specifically polydeoxyribonucleotides or PDRN is a trending skincare ingredient extracted from salmon sperm, PDRN is bio-identical to human, often used as injectable or topical when combined other treatments. It's gaining popularity, particularly in some European countries and Korea, for mimicking human stem cells and its potential to promote skin regeneration, reduce inflammation, and improve overall skin health, in most cases is now often use in place of stem cells.
Here's a more detailed look:
· What it is:
Salmon DNA or PDRN is a form of DNA extracted from salmon, most commonly from their gonads (sperm).
· Why it's used:
The nucleotides in salmon DNA are similar to human DNA, making them highly compatible with our skin. This allows them to potentially boost cell repair, regeneration, and anti-inflammatory effects.
· How it's used:
· Injectable Treatments: Salmon DNA can be injected into the skin to rejuvenate and improve skin texture.
· Topical Applications: It's also used in serums and masks for topical application, being of course more beneficial after procedures like laser or microneedling.
· Skin Benefits:
· Rejuvenation: May help improve overall skin health and radiance.
· Hydration: Can increase skin hydration and plumpness.
· Scars: May help improve acne scarring.
· Wrinkles: Could potentially help reduce the appearance of wrinkles and fine lines.
· Anti-Inflammatory: May have anti-inflammatory effects, potentially beneficial for conditions like acne and rosacea and are believed to have regenerative and reparative properties.
Other Potential Benefits
Skin regeneration: It may help stimulate the growth of new, healthy skin cells.
Anti-aging: It's thought to boost collagen production, which can improve skin elasticity and firmness, reducing wrinkles and fine lines.
Anti-inflammatory effects: This may help soothe irritated skin and manage conditions like acne or rosacea.
Wound healing and scar treatment: Its regenerative properties could aid in tissue repair, potentially improving the appearance of scars.
Hydration: It's believed to improve the skin's ability to retain moisture, which is crucial for healthy skin.
Improved Skin Texture and Tone: It can help even out skin tone and refine texture, leading to a brighter, more radiant complexion.
Reduced appearance of dark spots and uneven tone: It supports the skin's natural defenses against environmental stressors.
Safety and Side Effects:
While considered safe when administered by a licensed professional, allergic reactions are possible, especially for those sensitive to fish or seafood.
Side effects are generally mild and temporary, such as redness, swelling, or minor bruising, particularly when injected.
It's crucial to consult with a dermatologist to ensure the treatment is suitable for your skin type and health conditions.
How it differs from other treatments:
Compared to fillers and Botox: Salmon DNA treatment focuses on natural regeneration and healing, unlike fillers that add volume or Botox that reduces muscle activity.
Compared to hyaluronic acid: While hyaluronic acid provides immediate hydration, salmon DNA enhances moisture retention over time due to its regenerative properties.
Can be combined with other treatments: It can be used alongside procedures like microneedling or laser resurfacing to enhance results.
In essence, Salmon DNA is a promising ingredient in skincare due to its potential to stimulate the skin's natural repair mechanisms and promote overall skin health and appearance, but more research is needed to fully understand its long-term benefits and risks.
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